From the South ( Syracuse area) North on Interstate 81 to Adams Center Exit 42, East on Route 177 to Route 12S at West Lowville , follow Route 12 into Lowville.

  From the South ( Oneida – Rome area) North on Route 26 to Lowville

  From the South ( Utica area) North on Route 12 to Lowville

  From the East (Old Forge area) Route 28 to McKeever, Moose River Road to Port Leyden, North on Route 12 to Lowville

  From the North (Clayton area) South on Route 12 to Lowville

  From the North ( Alexandria Bay area) South on Interstate 81 to Exit 47, Route 12 South to Lowville

From Canada (Kingston area) the bridge to the US to Alexandria Bay, South on Interstate 81 to Exit 47, Route 12 South to Lowville